On that subject, here's an interesting case...
https://www.dragzine.com/news/street-outlaws-jj-daboss-recovering-after-violent-highway-accident/
Probably not the first time that dude drove like that, but was nearly was the last. Totaled three vehicles and probably the trailer in the crash. Open trailers like that, though expensive, aren't much to them. So that might not have been totaled.
Personally, I used to use "tricks" like rolling down all the windows (25F outside) and cranking up the music (600W RMS). I'd also periodically, still staring down the road, would move my head all around, in effect moving my eyeball around without loosing sight of the road. It's that unyielding thousand yard stare that can unwittingly turn into the 0.005mm stare. So I made it a point to recognize that "droning" gaze. Moving the eyeballs about helps stave that off. (note the word, "stave") There's been a couple of times I've just took an exit to the next fuel station to nap.